RNA Details
Disease Name
Hypertension Pulmonary
Tissue
lung
RNA Symbol
FGA
RNA ID
RNA Type
mRNA
Alteration Pattern
dysregulation
Species
homo sapiens
Detection Methods
Dual-luciferase reporter assay; etc.
Target
NA
Pathway
NA
PubMed ID
Title
Susceptibility to chronic thromboembolic pulmonary hypertension may be conferred by miR-759 via its targeted interaction with polymorphic fibrinogen alpha gene
Year
2010
Function
"A deletion/insertion (Del/Ins) polymorphism of 28 base pairs (bp) in the 3' untranslated region (UTR) of fibrinogen alpha gene (FGA) was associated with thromboembolic diseases. The expression of FGA was regulated by miR-759 through its interaction at the polymorphic 3'UTR sequence, which was associated with the susceptibility to CTEPH. And the effect of miR-759 was stronger on the Ins allele than on the Del allele."